Enalapril maleate

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CHEMICAL NAME
1-{N-[(S)-1-Ethoxycarbonyl-3-phenylpropyl]-L-alanyl} -L-proline maleate

FORMULA
C₂₀H₂₈N₂O₅.C₄H₄O₄

DESCRIPTION
White to off-white, crystalline powder.

SPECIFICATIONS
The product meets USP and Ph. Eur. requirements.

PHARMACOLOGICAL PROPERTIES
Enalapril maleate is the maleate salt of enalapril, a derivative of two aminoacids, L- alanine and L-proline. It belongs to the group of angiotensin-converting enzyme inhibitors (ACE inhibitors). Inhibition of ACE results in decreased plasma angiotensin II, increased plasma renin activity (removal of negative feedback on renin) and in decreased aldosterone secretion. The antihypertensive effect of enalapril maleate results primarily from suppression of the renin-angiotensin-aldosterone system which plays the principal role in regulation of blood pressure, although enalapril maleate is antihypertensive even in patients with low-renin hypertension.

USES
Enalapril maleate is used for the treatment of hypertension or heart failure. It is also used for the prevention of development of heart failure. In many patients with symptoms of heart failure enalapril maleate delays deterioration of the condition, decreases the incidence of hospitalization for heart failure, improves survival and quality of life.

INDICATIONS

• essential hypertension of all degrees
• renovascular hypertension
• heart failure of all degrees
• prevention of symptomatic heart failure
• prevention of coronary ischemic incidences in patients with left ventricular dysfunction

PRESENTATION
Double polyethylene bags inserted in multi-layer bags in drums.

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