Gentamicin sulphate is the sulphate salt, or a mixture of such salts, of the antibiotic substances produced by the growth of Micromonospora purpurea. It consists of

Gentamicin C1	:	C21H43N5O7, mol. weight 477.61
Gentamicin C2	:	C20H41N5O7, mol. weight 463.58
Gentamicin C1a	:	C19H39N5O7, mol. weight 449.55
Gentamicin C2a	:	C20H41N5O7, mol. weight 463.58

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DESCRIPTION
A white (or almost white powder).

SPECIFICATIONS
The product meets the USP and Ph. Eur. requirements.

PHARMACOLOGICAL PROPERTIES
Gentamicin sulphate is a broad spectrum bactericidal antibiotic of the aminoglycoside group. It is readily absorbed and reaches maximum serum concentrations within 30 - 90 minutes after intramuscular administration. Effective concentrations in the blood persist for 6 - 8 hours. About 90 % of gentamicin is excreted unchanged in urine by glomerular filtration.

The spectrum of action of gentamicin sulphate includes gram-positive and gram-negative bacteria. It acts reliably upon Pseudomonas aeruginosa, the Klebsiella-Enterobacter-Serratia group of bacteria, Escherichia coli, indole-positive and indole-negative strains of proteus, and less reliably upon Salmonella, Shigella, gonococci and staphylococci including Staphylococcus aureus.

USES
Gentamicin is used in the treatment of:

• septicemia and neonatal sepsis,
• severe, complicated and recurring infections of the urinary tract, the lower respiratory tract and the gastrointestinal tract (including peritonitis),
• infections of the skin, bones and soft tissues,
• burn wounds,
• infections of the central nervous system (including meningitis).

Gentamicin sulphate is available in ampoules, vials, ointment, ophthalmic ointment, and cream.

PRESENTATION
Aluminium bottles (sterile packaging) of 1 or 5 kg of gentamicin sulphate.

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